Amedica and Celling Biosciences to Collaborate on Silicon Nitride-Based Spinal Fusion Devices
Amedica Corp. recently announced a collaboration with Celling Biosciences to research and develop biologically enhanced implants. As part of the initial phase of the collaboration, Celling Biosciences’ team of scientists produced research indicating mesenchymal stem cells can be optimized and proliferate when using silicon nitride compared to the current polyetheretherketone (PEEK) and titanium biomaterial standards.
Results from the recent in vivo scientific study reportedly show that Amedica’s silicon nitride composition significantly outperformed PEEK in attachment testing of mesenchymal stem cells. Amedica’s biomaterial contains natural nano-surface topography and chemistry that play an active role in implant integration. The results of the study suggest the microenvironment of silicon nitride promotes better cell adhesion and compatibility with five times greater cell adhesion compared to the PEEK material used. With the initial research phase completed, Celling Biosciences will then translate the early findings to clinical trials in spinal and orthopedic applications. This collaborative research will further define the clinical advantages of silicon nitride in combination with stem cell-based therapies. Based on further scientific findings, the intellectual property from both partners could be leveraged to create innovative solutions that promote a robust nanotechnology.
“As an industry, we continue to strive for innovation beyond current standards, and Celling Biosciences has always focused on innovating standards of the future,” said Kevin Dunworth, CEO of Celling Biosciences. “Current trends show many evolutions of surface modifications and surface treatments around PEEK and titanium, but we believe Amedica’s proprietary technology is the future progression of biologically enhanced implants. Coupled with our ability to process tissue and apply those cells to cell-centric materials, such as silicon nitride, we look forward to further collaboration and optimizing the environment for healing.”