SCHOTT Doubles Production Capacity for Coated Vials
According to the company, its new production environment is fully automated, strictly avoids glass-to-glass contact, and focuses on the reduction of particle load.
SCHOTT recently announced that it has enhanced its production setup for coated vials. Due to a growing number of highly sensitive parenteral drugs requiring special packaging solutions, interest in vials with inner coatings is steadily on the rise. To meet this demand, SCHOTT offers vials with a particularly inert inner surface or special surface properties for lyophilization. According to the company, its new production environment is fully automated, strictly avoids glass-to-glass contact, and focuses on the reduction of particle load.
Creating a chemically stable inner container surface is an ongoing quest for pharmaceutical packaging manufacturers. “Quartz coatings offer a great way to combine well-known, highly processable borosilicate glass with the pureness of SiO2 (silicon dioxide), creating a very homogeneous surface,” said Florence Buscke, global product manager for Vials & Coatings. “This enables us to create a functional barrier to minimize drug and container interaction.”
SCHOTT Type I plus® vials with a quartz-like inner surface are available in sizes ranging from 2-100 ml. They reportedly ensure that the formulation remains stable over its shelf life by reducing ion leaching and protein adsorption. In addition, they can help pharma companies avoid a pH-shift for unbuffered formulations.
According to SCHOTT, lyophilization is a second area where coated vials can demonstrate an advantage. SCHOTT TopLyo® vials are provided with a hydrophobic inner layer. This reportedly ensures that liquid residues are drawn together to form larger drops, similar to the so-called lotus effect. The result is a compact and aesthetic lyo cake, as well as less fogging at the container walls. In addition, the hydrophobic layer also enables easier emptying and leaves less residual volume after reconstitution, which reduces the need for overfilling. Lastly, SCHOTT TopLyo vials avoid any residual silicone due to the silicone-free coating technique.
For more information, visit www.schott.com.